Complication of Nephrotic Syndrome

Complication of primary Nephrotic Syndrome 

simple . easy made , Mnemonics

Complications : A B C + S I R
 
 5 A

• Acute R. failure (esp.FGS)
• Anaemia (loss of transferrin in urine).
• Atherosclerosis.
• Abdominal pain .
• Abnormal growth & Nutrition.

 1 B

• Bleeding tendency ( loss of cloting Factors 9, 11 , 12 ).

 2 C

• Coagulation abnormality & thrombotic tendency .

1. ‎↓ antithrombin III.
2. ‎↑ platelet aggregation.
3. ‎↑ inhibitors of fibrinolysis.

• Cataract (due to steroids).

 2 S

• Shock ( Hypovolemic due to rapid diuresis).
• Skin infection & diseases .

 1 I →

• ↑ Infection liability (the most common
• cause

Due to :

• ‎Immuno-suppresive drugs.
• ‎↓ bactericidal activity of WBC`s .
• ‎defective oppsonization.
• ‎Hyposplenism.

*the most common infection ( pneumococcal peritonitis ) .
*the most common site ( peritoneum , skin ).
*the most common organism ( pneumococci , E-coli).
 2 R

• Relapse (either lab. → heavy proteinuria & or clinical →oedema) .
• Renal – tubular disorder.