Complication of Nephrotic Syndrome

Saturday, May 5, 20120 comments

Complication of primary Nephrotic Syndrome 
simple . easy made , Mnemonics
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Complications : A B C + S I R
 
 5 A
  • Acute R. failure (esp.FGS)
  • Anaemia (loss of transferrin in urine).
  • Atherosclerosis.
  • Abdominal pain .
  • Abnormal growth & Nutrition.
 1 B
  • Bleeding tendency ( loss of cloting Factors 9, 11 , 12 ).
 2 C
  • Coagulation abnormality & thrombotic tendency .
  1. ‎↓ antithrombin III.
  2. ‎↑ platelet aggregation.
  3. ‎↑ inhibitors of fibrinolysis.
  • Cataract (due to steroids).
 2 S
  • Shock ( Hypovolemic due to rapid diuresis).
  • Skin infection & diseases .
 1 I


  • ↑ Infection liability (the most common
  • cause
Due to :
  • ‎Immuno-suppresive drugs.
  • ‎↓ bactericidal activity of WBC`s .
  • ‎defective oppsonization.
  • ‎Hyposplenism.
*the most common infection ( pneumococcal peritonitis ) .
*the most common site ( peritoneum , skin ).
*the most common organism ( pneumococci , E-coli).
 2 R
  • Relapse (either lab. → heavy proteinuria & or clinical →oedema) .
  • Renal – tubular disorder.
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