Rheumatic Arthritis

Sunday, May 20, 20120 comments

Definition :Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unknown cause. The hallmark feature of this condition is persistent symmetric polyarthritis (synovitis) that affects the hands and feet, although any joint lined by a synovial membrane may be involved. Extra-articular involvement of organs such as the skin, heart, lungs, and eyes can be significant.

Etiology :

The cause of RA is unknown. Genetic, environmental, hormonal, immunologic, and infectious factors may play significant roles. Socioeconomic, psychologic, and lifestyle factors may influence disease outcome.

Epidemiology :

  • The annual incidence is approximately 3 cases per 10,000 population.
  • The prevalence rate is approximately 1%, increasing with age and peaking at age 35-50 years.
  • Women are affected by RA approximately 3 times more often than men.
Pathogensis :

  • The pathogenesis of RA is not completely understood.
  • An external trigger (eg, infection, trauma) that triggers an autoimmune reaction
  • leading to synovial hypertrophy and chronic joint inflammation along with the potential for extra-articular manifestations.

  • Is theorized to occur in genetically susceptible individuals.
  • Synovial cell hyperplasia and endothelial cell activation are early events in the pathologic process
  • Genetic factors and immune system abnormalities contribute to disease propagation.
  • Abnormal production of numerous cytokines, chemokines, and other inflammatory mediators has been Demonstrated in patients with RA.
  • Inflammation and exuberant proliferation of synovium leads to destruction of various tissues, including cartilage, bone, tendons, ligaments, and blood vessels.

    By Dr Shall

Share this article :

Post a Comment

Support : Creating Website | Johny Template | Mas Template
Copyright © 2011. Medical Show - All Rights Reserved
Template Created by Creating Website Published by Mas Template
Proudly powered by Premium Blogger Template